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The City of Industry is situated at the intersection of Los Angeles, Orange, San Bernardino, and Riverside Counties. The City of Industry is conveniently located along the most important transportation and logistics corridor in the United States for moving products and materials from Asia, Mexico and the Pacific Coast to the eastern United States. The City's position at the Los Angeles and Orange County borders ensures a highly educated and diverse workforce with high quality housing in surrounding communities.

Firms in the city are serviced by both the Union Pacific and Southern Pacific transcontinental railroads, both running westerly to Los Angeles and easterly toward Riverside. Southern Pacific operates a mainline switching yard and major intermodal (piggy-back) facility in the City of Industry which cuts delivery and transit times substantially. In addition, a 41-mile rail bypass opens the City of Industry directly into both of the West Coast's largest seaports - the Ports of Los Angeles and Long Beach. 

The City of Industry is bordered by many major freeways and highways:  Interstate 10, the Pomona Freeway (State Route 60), the San Gabriel River Freeway (Interstate 605), the Orange Freeway (State Route 57), and the Chino Valley Freeway (State Route 71).

More than 50 major trucking lines are franchised to serve the area. Overnight delivery can be made to all major California cities, as well as Phoenix, Arizona and Las Vegas, Nevada.  The City of Industry allows 24 hour a day business operations, on roads that are designed for large truck operations and are of excellent quality.

Local and Los Angeles area bus service is provided by the Metropolitan Transit Authority (METRO) and Foothill Transit. In addition, Metrolink, a commuter rail line which serves communities in Ventura, Los Angeles, Orange, San Bernardino and Riverside Counties, has a station in the city.  The City of Industry Metrolink station is the busiest station in the entire Metrolink system.

Air transportation is available at any of the leading airports serving the greater Los Angeles area as well as several local private airports. The City of Industry is located 18 miles from Ontario International Airport, 34 miles from Hollywood Burbank Airport, and approximately 40 miles from both Los Angeles International Airport and John Wayne Airport. The airports have excellent air freight facilities. Private aircraft facilities are also available at Brackett Field in La Verne, 9 miles away, and El Monte Airport, just 8 miles away.